Does ‘Type 1.5 diabetes’ have an autoimmune cause like Type 1, but a slow, adult-onset pattern like Type 2?

1. The Diabetes Between Type 1 and Type 2
LADA (Latent Autoimmune Diabetes in Adults) is often called ‘Type 1.5 diabetes’ to make it easier for patients to understand. As its nickname suggests, it is a special type of diabetes that has characteristics of both Type 1 and Type 2, and is therefore easily mistaken for Type 2 diabetes.

2. The Two Features of LADA
– Cause like Type 1: ‘Autoimmune attack’: The cause of the disease is that the body’s own immune cells attack the insulin-producing cells in the pancreas. Therefore, evidence of this attack, ‘autoantibodies,’ can be found in a blood test.
– Onset like Type 2: ‘Slow and gradual’: However, the pancreatic cells are not destroyed rapidly as in Type 1, but break down very slowly over several years. For this reason, it usually develops in adults over 30, and initially, blood sugar seems to be somewhat manageable with diet or oral medication, just like Type 2 diabetes.

3. Why an Accurate Diagnosis is Crucial
If initially misdiagnosed as Type 2, medications that ‘squeeze’ the pancreas to produce more insulin might be used. This can exhaust the already struggling pancreas more quickly, actually hastening the need for insulin injections. Therefore, if a lean adult is diagnosed with diabetes, or if blood sugar control continues to worsen despite taking Type 2 diabetes medication, it is important to check for the possibility of ‘Type 1.5 diabetes’ through an autoantibody test. Ultimately, these patients, like those with Type 1, will require insulin therapy over time.

Summary: ‘Type 1.5 diabetes (LADA)’ is similar to Type 2 on the surface, but its cause is an autoimmune disease like Type 1. An accurate diagnosis is crucial as the treatment approach can be different.


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대한당뇨병학회 https://diabetes.or.kr/
질병관리청 https://www.kdca.go.kr/
국립보건연구원 https://nih.go.kr/
대한영양사협회 https://www.dietitian.or.kr/
대한내분비학회 https://www.endocrinology.or.kr/
대한스포츠의학회 https://www.sportsmed.or.kr/
대한신경과학회 https://www.neuro.or.kr/english/
대한정신건강의학회 https://www.knpa.or.kr/
대한치주과학회 https://www.kperio.org/main/main.php/
대한수면의학회 https://www.sleep.or.kr/html/?pmode=intro/
대한신장학회 https://www.ksn.or.kr/

미국당뇨병학회 https://diabetes.org/
영국당뇨병학회 https://www.diabetes.org.uk/
미국안과학회 https://www.aao.org/
미국치과의사협회 (American Dental Association) https://www.ada.org/
국제항공운송협회 (IATA) https://www.iata.org/
미국 질병통제예방센터 (CDC) https://www.cdc.gov/
미국심장협회 (American Heart Association) https://www.heart.org/
세계보건기구 (WHO) https://www.who.int/
국제표준화기구 (ISO) https://www.iso.org/
인슐린 제조사 https://www.lilly.com/
미국소화기학회 (American Gastroenterological Association) https://www.gastro.org/
미국식품의약국 (FDA) https://www.fda.gov/
미국족부의학회 (American Podiatric Medical Association) www.apma.org/
미국 산부인과 학회 (American College of Obstetricians and Gynecologists) https://www.acog.org/
미국대사수술학회 (American Society for Metabolic and Bariatric Surgery) https://asmbs.org/

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